To upload to Artifactory, an entry for each repository needs to be made in $HOME/.pypirc as follows:
[distutils]
index-servers =
local
pypi
[pypi]
repository: https://pypi.org/pypi
username: mrBagthrope
password: notToBeSeen
[local]
repository: http://localhost:8081/artifactory/api/pypi/pypi-local
username: admin
password: password
Notice that the URL does not end with /simple.
The HOME environment variable
setuptools requires that the .pypirc file be found under $HOME/.pypirc, using the HOME environment variable.
On unix-like systems this is usually set by your system to /home/yourusername/ but in certain environments such as build servers you will have to set it manually.
On Windows it must be set manually.