There is a condition that can happen that causes replication to time out, usually when dealing with large files. Error:
Error occurred while performing folder replication for 'local-repo:': Read timed out: Read timed out"
This can be resolved by altering two time-out settings. In the replication configuration, increase the Socket Timeout to a large number (try increasing to 1 hour:
In your proxy server and/or load balancer you will want to increase the "send timeout" values.